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I suspect that you, my friend, just saw your first case of DIC. It can happen from a lot of things, especially in the patient you just presented (fulminant sepsis or hepatitis, massive GI bleed, lotsa other stuff, etc.) Airway control was probably a good thing, but she needed RSI and I don't...

I don't know that anyone has studied it. Narcan is a weird and dangerous drug. The workings of the endogenous opioid systems are complex and intertwined with multiple other systems in the body, as you likely know. And I think narcan's pharmacodynamics are varied from person to person...