SGwinn96

Mebendazole (MZ) (methyl 5-benzoyl-2-benzimidazole-carbamate) is a broad-spectrum anthelmintic (antiworm) drug. It is used to inhibit the growth and multiplication of newly hatched insects in your body. It promotes the depolymerization of tubulin and destroys the function of microtubules in insects. Benzimidazole has two derivatives MZ and albendazole. MZ has anticancer activity. It causes mitotic arrest in cancerous cells that leads to cell death. It is very effective against lung cancer.

Non-small cell lung cancer
Lung cancer is one of the leading causes of death all over the world. Non-small cell lung cancer (NSCLC) is very common kind (85%) of lung cancer in smokers and non-smokers. It is more common in females than in males. NSCLCs have a very poor prognosis and such patients are less sensitive to chemotherapy as compared to small cell carcinoma.

Mechanism of Action
Scientific studies have shown that MZ prevents the normal spindle formation in NSCLC by inhibiting the polymerization of tubulin. This abnormal spindle formation causes mitotic arrest at prometaphase of cell division and ultimately leads to cell death. Mebendazole also induces phosphorylation and produces changes in the expression of cell cycle regulatory proteins that are also associated with the mitotic arrest.
https://www.fenbendazole.org/2019/12/19/anti-cancerous-effect-of-mebendazole/