Oxygen Therapy in Critical Illness
Precise Control of Arterial Oxygenation and Permissive Hypoxemia
Daniel Stuart Martin, BSc, MBChB, PhD, FRCA, FFICM, Michael Patrick William Grocott, MBBS, MD, FRCA, FRCP, FFICM
Disclosures
Crit Care Med. 2013;41(2):423-432.
"Supranormal arterial oxygenation is also associated with a number of cardiovascular responses such as reduced stroke volume and cardiac output,[43,44] increased peripheral vascular resistance,[43] coronary artery vasoconstriction, and reduced coronary blood flow,[45,46] which may be undesirable in critically ill patients.
A growing body of clinical evidence points to the potential harm of using high concentrations of inspired oxygen in clinical situations where classical teaching and physiological intuition might suggest a beneficial response."
Precise Control of Arterial Oxygenation and Permissive Hypoxemia
Daniel Stuart Martin, BSc, MBChB, PhD, FRCA, FFICM, Michael Patrick William Grocott, MBBS, MD, FRCA, FRCP, FFICM
Disclosures
Crit Care Med. 2013;41(2):423-432.
"Supranormal arterial oxygenation is also associated with a number of cardiovascular responses such as reduced stroke volume and cardiac output,[43,44] increased peripheral vascular resistance,[43] coronary artery vasoconstriction, and reduced coronary blood flow,[45,46] which may be undesirable in critically ill patients.
A growing body of clinical evidence points to the potential harm of using high concentrations of inspired oxygen in clinical situations where classical teaching and physiological intuition might suggest a beneficial response."